GRIN1 (NP_015566, 21 a.a. ~ 120 a.a) partial recombinant protein with GST tag. The sequence is ACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCE DLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
Pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events; Alzheimers disease; Amphetamine addiction; BDNF signaling pathway
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