Specifications
Species Reactivity
Mouse, Rat, Human
Immunogen
Fusion protein corresponding to Rat NMDAR1 aa 42-361 (extracellular). NP_058706.1Sequence: FREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAIL VSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTV PPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKA EKVLQFDPGTK
Applications
Application Notes
IHC-P: 0.1 - 1 μg/ml; WB: 1 μg/ml; IHC-Fr: 0.1 - 1 μg/ml.
Target
Alternative Names
GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; glutamate [NMDA] receptor subunit zeta-1; NMD-R1; neurotransmitter receptor; NMDA R1 receptor C1 cassette; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor subunit NR1; N
Product Background
Antigen Description
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.
Pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem;
Citations
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Masuho, I; Mototani, Y; et al. Dynamic expression patterns of G protein-regulated inducer of neurite outgrowth 1 (GRIN1) and its colocalization with G alpha o implicate significant roles of G alpha o-GRIN1 signaling in nervous system. DEVELOPMENTAL DYNAMICS 237:2415-2429(2008).
Chen, LT; Gilman, AG; et al. A candidate target for G protein action in brain. JOURNAL OF BIOLOGICAL CHEMISTRY 274:26931-26938(1999).
COA
Certificate of Analysis
