Product Overview
Human C1 Esterase Inhibitor (C1-INH)
Tag/Conjugate
Unconjugated
Concentration
1.0 mg/ml (see Certificate of Analysis for actual concentration)
Buffer
10 mM sodium phosphate, 145 mM NaCl, pH 7.3
Storage
2-8°C short term, -20°C long term
Introduction
Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
Antigen Description
The protease inhibitor C1-INH prevents the spontaneous activation of complement and limits consumption of C2 and C4 by rapidly inactivating C1r, C1s and MASP2. It is the only plasma serine protease inhibitor (Serpin) capable of interacting with and inhibi
Keywords
SERPING1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; C1IN; C1NH; HAE1; HAE2; C1INH; plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhib
Citations
Publication ()
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COA
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