Anti-SERPING1 monoclonal antibody, clone 5H13

Antibody Isotype

IgG1

Clone

5H13

Species Reactivity

Human

Immunogen

C1 inhibitor protein purified from Human plasma

Conjugate

Alternative Names

SERPING1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; C1NH, serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary); plasma protease C1 inhibitor; angioedema; hereditary; C1 INH; C1IN; HAE1;

Entrez Gene ID

UniProt ID

Antigen Description

C1 inhibitor (C1-INH) is a serine protease inhibitor that inactivates several different proteases in the complement, contact, coagulation, and fibrinolytic systems. Though C1-INH has 478 residues (53kDa), the circulating protein is approximately 104 kDa by post-translational modification. Deficiency of C1-INH results in hereditary angioedema. In addition, C1-INH may prove useful in a variety of other diseases including septic shock, reperfusion injury, hyperacute transplant rejection, traumatic and hemorrhagic shock.

Pathway

Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Hemostasis, organism-specific biosystem; Intrinsic Pathway, organism-specific biosystem; Pertussis, organism-specific biosystem;