Mouse Anti-Varicella Zoster Virus (VZV/chickenpox) IgG ELISA kit

Sample

Serum or plasma

Species Reactivity

Mouse

Detection Method

iELISA

Intended Use

For the detection of mouse IgG antibodies against Varicella zoster in serum and plasma.

Storage

The microtiter well plate and all other reagents are stable at 2-8°C until the expiration date printed on the label. The whole kit stability is usually 12 months from the date of shipping under appropriate storage conditions. The unused portions of the standards should be stored at 2-8°C or stored frozen in small aliquots and should be stable for 3 months.

Precision

Intraassay: <4.55%
Interassay: <6.81%

General Description

Varicella-zoster virus (VZV) is known by many names, including chickenpox virus, varicella virus, zoster virus, and human herpes virus type 3 (HHV-3). VZV is closely related to the herpes simplex viruses (HSV), sharing much genome homology. It is one of eight
herpes viruses known to infect humans and other vertebrates. It commonly causes chickenpox in children and adults and herpes zoster (shingles) in adults and rarely in children. As with the other herpes viruses, VZV causes both acute illness and lifelong latency. Before vaccination became widespread, acute primary infection (varicella or "chickenpox") was common during childhood--especially in temperate climates. Varicella usually is a benign and self-limiting illness but can be more severe in adults and in individuals with cellular immunodeficiency. These individuals are at much higher risk of pneumonia and disseminated disease with visceral involvement. Zoster typically presents as a painful, localized cutaneous eruption occurring along 1 or more contiguous dermatomes. Humans are the only known natural hosts of VZV. Transmission of VZV occurs through direct contact with infectious lesions or by inoculation of aerosolized infected droplets onto a susceptible mucosal surface.
The known envelope glycoproteins (gB, gC, gE, gH, gI, gK, gL) correspond with those in HSV; however, there is no equivalent of HSV gD. The most popular test detects VZVspecific IgM antibody in blood; this appears only during chickenpox or herpes zoster and not while the virus is dormant.
CD's anti ZVZ IgG ELISA kit is an enzyme immunoassay for the quantitative determination of IgG class antibodies against Varicella Zoster Virus (chickenpox) in mouse serum or plasma. ADI also has separate ELISA kits to measure IgA and IgM classes.