Specifications
Antibody Isotype
IgG1, kappa
Applications
Application Notes
ELISA, FACS, FuncS, Reference antibody
Each laboratory should determine an optimum working titer for use in its particular application.
Other applications have not been tested but use in such assays should not necessarily be excluded.
General Notes
Ponsegromab (PF 06946860) is a potent and selective humanized anti-GDF15 monoclonal antibody with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to GFRAL, thereby blocking GDF15/GFRAL-mediated signaling. Ponsegromab can be used in the research of cancers.
Target
Alternative Names
Ponsegromab; PF 06946860; GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Grgurevic, L; Macek, B; et al. Circulating Bone Morphogenetic Protein 1-3 Isoform Increases Renal Fibrosis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 22:681-692(2011).
Kempf, T; Horn-Wichmann, R; et al. Circulating concentrations of growth-differentiation factor 15 in apparently healthy elderly individuals and patients with chronic heart failure as assessed by a new immunoradiometric sandwich assay. CLINICAL CHEMISTRY 53:284-291(2007).
COA
Certificate of Analysis
