Product Overview
Recombinant human GDF15 protein is produced by Mammalian expression system and the target gene encoding Ala197-Ile308 is expressed with a His-tag at the N-terminus.
Alternative Names
Growth differentiation factor 15; GDF-15; Macrophage inhibitory cytokine 1; MIC-1
Purity
> 90 % as determined by SDS-PAGE
Concentration
Batch dependent - please inquire should you have specific requirements
Buffer
10mM sodium acetate, 10% glycerol, pH 4.0
Storage
Store at -20°C to -80°C
Introduction
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1). Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1β, tumor necrosis factor α (TNF-α), interleukin 2, and macrophage colony-stimulating factor but not interferon γ, or lipopolysaccharide (LPS). It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF-15 level is linked with the progression and prognosis of the disease condition.
Keywords
Growth differentiation factor 15; GDF15; Cardiovascular
Citations
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