Anti-GDF15 monoclonal antibody, clone 34C4E3.I6

Antibody Isotype

IgG1

Clone

34C4E3.I6

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region near the carboxy terminal end of Human GDF15 protein. A residue of cysteine was added to facilitate coupling to KLH.

Conjugate

Application Notes

WB: 1/1000;

Alternative Names

GDF15; growth differentiation factor 15; growth/differentiation factor 15; MIC 1; MIC1; NAG 1; PDF; PLAB; prostate differentiation factor; PTGFB; NRG-1; PTGF-beta; placental TGF-beta; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; macroph

Entrez Gene ID

UniProt ID

Antigen Description

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.

Pathway

Direct p53 effectors, organism-specific biosystem;