Molecular Weight
15.19 kDa
Purity
> 95% as determined by SDS-PAGE
Buffer
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization
Introduction
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1). Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1β, tumor necrosis factor α (TNF-α), interleukin 2, and macrophage colony-stimulating factor but not interferon γ, or lipopolysaccharide (LPS).
Keywords
Growth differentiation factor 15; GDF15; Cardiovascular
Citations
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Barderas, R; Mendes, M; et al. In-depth Characterization of the Secretome of Colorectal Cancer Metastatic Cells Identifies Key Proteins in Cell Adhesion, Migration, and Invasion. MOLECULAR & CELLULAR PROTEOMICS 12:1602-1620(2013).
Tsai, VWW; Husaini, Y; et al. Anorexia/cachexia of chronic diseases: a role for the TGF-beta family cytokine MIC-1/GDF15. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE 3:239-243(2012).
COA
Certificate of Analysis
