In vitro: The combination of pertuzumab with etoposide represents a promising strategy aimed at inhibition of viability and proliferation of gastric cancer cells. The mechanism of action includes induction of both extrinsic and intrinsic apoptotic pathway, where increased activity of caspase-8 and caspase-9 are demonstrated.
In vivo: Pertuzumab significantly inhibits tumor growth when combined with erlotinib. Pertuzumab treated DLD-1 xenograft tumors shows no enhanced necrosis, which is found in HCT116 derived xenografts.
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