Human HER2, neu (DAG260)

Human HER2, neu, recombinant protein from E. coli Datasheet

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Product Overview
RecombinantHuman HER2/neu (erbB-2). 43.4kDa protein containing 397 amino acid residuesof the human Herstatin. The amino acid sequence of the recombinant humanherstatin is 100% homologous to the amino acid sequence of the humanherstatin without signal sequ
Nature
Recombinant
Tag/Conjugate
Unconjugated
Format
Purified, Lyophilized; Reconstitute with deionized water to 0.5 mg/ml and let thelyophilized pellet dissolve completely (typically requires 20 minutes at 37°C). For conversion into higher pH values, we recommend intensive dilutionusing a relevan buffer to
Concentration
0.5 mg/ml (prior to lyophilization)
Buffer
Lyophilized from0.05M Acetate buffer, pH 4
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
This is an antibody fragment consisting of a single monomeric variable antibody domain directed to human ErbB2. Nanobody, with a molecular weight of only 12–15 kDa, is able to bind selectively to a specific antigen like a whole antibody.
Antigen Description
HER2/neu(also known as ErbB-2) stands for Human Epidermal growth factorReceptor 2 and is a protein giving higher aggressiveness in breastcancers. It is a member of the ErbB protein family, more commonly known asthe epidermal growth factor receptor family. HER2/neu has also beendesignated as CD340 (cluster of differentiation 340) and p185. It is encodedby the ERBB2 gene.
Keywords
ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NGL, v erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); receptor tyrosine-pr

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