Matched pair antibody available for Testosterone [HRP]: Testosterone antibody (Catalog # HMABPY021)
Format
Liquid
Concentration
Batch dependent - please inquire should you have specific requirements
Buffer
0.05M Tris, pH 7.0
Preservative
0.005% Thimerosal
Storage
Store at 2-8°C, do not freeze
Introduction
Testosterone is a steroid sex hormone found in both men and women. In men, testosterone is produced primarily by the Leydig (interstitial) cells of the testes when stimulated by luteinizing hormone (LH). It functions to stimulate spermatogenesis, promote physical and functional maturation of spermatozoa, maintain accessory organs of the male reproductive tract, support development of secondary sexual characteristics, stimulate growth and metabolism throughout the body and influence brain development by stimulating sexual behaviors and sexual drive. In women, testosterone is produced by the ovaries (25%), adrenals (25%) and via peripheral conversion from androstenedione (50%). Testerone in women functions to maintain libido and general wellbeing. Testosterone exerts a negative feedback mechanism on pituitary release of LH and follicle-stimulating hormone (FSH). Testosterone may be further converted to dihydrotestosterone or estradiol depending on the tissue.
Q: I am wondering at which position in the Testosterone does the HRP conjugation in a) Testosterone-3 HRP (DAG1309) b) 17a-Testosterone(3) HRP (DAG1000) occurred?
A: In both products the HRP moiety is attached at the C-3 position of the testosterone molecule.
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