Product Overview
Blocking/Immunizing peptide for anti-NFATC4 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Function
DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity;
Synonyms
NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; nuclear factor of activated T-cells, cytoplasmic 4; NFAT3; NF-AT3; T cell transcription factor NFAT3; T-cell transcription factor NFAT3; NF-ATc4;
Citations
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Joshi, N; Johnson, LL; et al. Gene expression differences in normal esophageal mucosa associated with regression and progression of mild and moderate squamous dysplasia in a high-risk Chinese population. CANCER RESEARCH 66:6851-6860(2006).
Desterke, C; Bilhou-Nabera, C; et al. FLT3-Mediated p38-MAPK Activation Participates in the Control of Megakaryopoiesis in Primary Myelofibrosis. CANCER RESEARCH 71:2901-2915(2011).