Anti-NFATC4 (aa 578-627) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: SQRSAQELPQ VEAYSPSACS VRGGEELVLT GSNFLPDSKV VFIERGPDGK, corresponding to amino acids 578-627 of Human NFATC4

Conjugate

Application Notes

IHC-P: 4 - 8 μg/ml; WB: 1.25 μg/ml.

Alternative Names

NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; nuclear factor of activated T-cells, cytoplasmic 4; NFAT3; NF-AT3; T cell transcription factor NFAT3; T-cell transcription factor NFAT3; NF-ATc4;

Entrez Gene ID

UniProt ID

Antigen Description

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.

Pathway

Axon guidance; B cell receptor signaling pathway; ErbB2/ErbB3 signaling events; HTLV-I infection;