Anti-SMC3 monoclonal antibody, clone 2H2

Antibody Isotype

IgG2a

Clone

2H2

Species Reactivity

Human

Immunogen

CSPG6 (AAH47324, 711 a.a. ~ 810 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

BAM; BMH; HCAP; CDLS3; CSPG6; SMC3L1; structural maintenance of chromosomes protein 3; SMC-3; SMC protein 3; OTTHUMP00000020477; chromosome-associated polypeptide; chondroitin sulfate proteoglycan 6 (bamacan); basement membrane-associated chondroitin prot

Entrez Gene ID

UniProt ID

Antigen Description

This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.
Mouse monoclonal antibody raised against a partial recombinant CSPG6.

Pathway

Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; DNA Replication, organism-specific biosystem; M Phase, organism-specific biosystem; Mitotic M-M/G1 phases, organism-specific biosystem