Anti-SMC3 polyclonal antibody [Agarose]

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide (Human) conjugated to KLH - which represents a portion of human Structural Maintenance of Chromosomes-3 encoded within exon 28 (LocusLink ID9126).

Conjugate

Application Notes

IP: Use at a concentration of 15 - 25 μg/ml. WB: Use at an assay dependant dilution. Predicted molecular weight: 141.5 kDa.

Alternative Names

SMC3; structural maintenance of chromosomes 3; chondroitin sulfate proteoglycan 6 (bamacan); CSPG6; structural maintenance of chromosomes protein 3; BAM; bamacan; bamacan proteoglycan; HCAP; SMC3L1; SMC-3; SMC protein 3; chromosome-associated polypeptide;

Entrez Gene ID

UniProt ID

Antigen Description

Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.

Pathway

Cell Cycle; Cell Cycle, Mitotic; Cell cycle; Chromosome Maintenance; DNA Replication; M Phase;