Anti-SMC3 (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Full length human SMC3 protein (AAH47324).

Conjugate

Application Notes

WB: 1 μg/ml. ICC/IF: 10 μg/ml.

Alternative Names

SMC3; structural maintenance of chromosomes 3; chondroitin sulfate proteoglycan 6 (bamacan) , CSPG6; structural maintenance of chromosomes protein 3; BAM; bamacan; bamacan proteoglycan; HCAP; SMC3L1; Basement membrane associated chondroitin proteoglycan;

Entrez Gene ID

UniProt ID

Antigen Description

This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.

Pathway

Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; DNA Replication, organism-specific biosystem; M Phase, organism-specific biosystem; Meiosis, organism-specific biosystem; Meiotic Synapsis, organism-specific biosystem; Mitotic M-M/G1 phases, organism-specific biosystem; Mitotic Metaphase/Anaphase Transition, organism-specific biosystem; Mitotic Prometaphase, organism-specific biosystem; Oocyte meiosis, organism-specific bi