General Notes
This product (Catalog No. DPABH-19193) is a rabbit-derived polyclonal antibody raised against human SMC3, targeting the amino acid region 1–349 of the protein. This antibody exhibits cross-reactivity with Human SMC3 from mouse and rat. It has been affinity purified by Protein A. This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008].
DPABH-19193 is suitable for use in Western blot (WB) (1:500–1:2,400), IHC (1:50–1:500), IF/ICC (1:50–1:500) applications.
DPABH-19193 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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