Anti-CXCR3 monoclonal antibody, clone 2D6

Antibody Isotype

IgM

Clone

2D6

Species Reactivity

Human

Immunogen

CXCR3 (-, 1 a.a. ~ 54 a.a) partial recombinant protein with GST tag.

Conjugate

Alternative Names

chemokine (C-X-C motif) receptor 3; CKR-L2; IP-10 receptor; G protein-coupled receptor 9; CD182; GPR9; Mig-R; CD183; C-X-C chemokine receptor type 3; CMKAR3; chemokine (C-X-C) receptor 3; IP10-R; IP10 receptor; MigR; Mig receptor; Interferon-inducible pro

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
Mouse monoclonal antibody raised against a partial recombinant CXCR3.

Pathway

CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem