Specifications
Immunogen
A 37 amino acid synthetic peptide corresponding to the N-terminus of Human CXCR3, conjugated to KLH.
Applications
Application Notes
WB: 0.5 - 2 μg/ml; IP: 2 - 5 μg/ml; ELISA: 0.1 - 1 μg/ml; IHC-P: 1/500; Flow Cyt: 2 - 5 μg/ml;
Target
Alternative Names
CXCR3; chemokine (C-X-C motif) receptor 3; G protein coupled receptor 9 , GPR9; C-X-C chemokine receptor type 3; CD183; CKR L2; CMKAR3; IP10 R; MigR; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine (C-X
Product Background
Antigen Description
Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC).Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). May play a role in angiogenesis.Isoform 3 mediates the activity of CXCL11.
Pathway
CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Citations
Publication ()
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COA
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