Anti-GBA monoclonal antibody (DMABT-H13823)

Mouse anti-Human GBA monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
3F3
Species Reactivity
Human
Immunogen
GBA (NP_000148, 146 a.a. ~ 235 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
GBA; glucosidase, beta, acid; GLUC, glucosidase, beta; acid (includes glucosylceramidase) , glucosylceramidase; glucosylceramidase; GBA1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GBA (Glucosylceramidase Beta) is a Protein Coding gene. Diseases associated with GBA include gaucher disease, type i and gaucher disease, type ii. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include receptor binding and glucosylceramidase activity. This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
Pathway
Glycosphingolipid metabolism, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Other glycan degradation, organism-specific biosystem.

Citations


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References


BERNSTEIN, K; BOLSHOUN, D; et al. DETECTION OF GLOMERULAR-BINDING IMMUNE ELEMENTS IN MURINE LUPUS USING A TISSUE-BASED ELISA. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 91:449-455(1993).
Banoub, J; Combden, S; et al. Structural characterization of intact covalently linked DNA abducts by electrospray mass spectrometry. NUCLEOSIDES & NUCLEOTIDES 18:2751-2768(1999).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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