General Notes
This product (Catalog No. DPABH-08196) is a rabbit-derived polyclonal antibody raised against human GBA, targeting the amino acid region 117–214 of the protein. This antibody exhibits cross-reactivity with Human GBA from mouse and rat. It has been affinity purified by Protein A. Lysosomal acid glucosylceramidase (GCase or acid β-glucosidase) is a critical hydrolase enzyme located in the lysosome that breaks down the sphingolipid glucocerebroside into glucose and ceramide. It is essential for cellular membrane turnover and lipid metabolism. Defects in the GBA1 gene reduce GCase activity, causing lipid buildup and resulting in Gaucher disease (lysosomal storage disorder) or increased risk of Parkinson's disease.
DPABH-08196 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-08196 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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