p53 protein acts as a tumor suppressor in many tumor types and induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Defects in TP53 are found in many types of cancers.
Pathway
AMPK signaling; Activation of NOXA and translocation to mitochondria; Alzheimers Disease; Amyotrophic lateral sclerosis (ALS)
Citations
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