Anti-TP53 monoclonal antibody

Antibody Isotype

IgG2a

Clone

Cq54-12

Species Reactivity

N/A

Conjugate

Unconjugated

Alternative Names

TP53; tumor protein p53; P53; LFS1; TRP53; cellular tumor antigen p53; antigen NY-CO-13; phosphoprotein p53; p53 tumor suppressor; transformation-related protein 53; Li-Fraumeni syndrome; p53; protein 53; FLJ92943; OTTHUMP00000221333; OTTHUMP00000221334;

Entrez Gene ID

7157

UniProt ID

K7PPA8

Antigen Description

This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it"s believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. Recombinant human p53 (transcription domain within the NH2 terminus)

Pathway

Activation of BH3-only proteins; Activation of NOXA and translocation to mitochondria; Activation of PUMA and translocation to mitochondria; Amyotrophic lateral sclerosis (ALS); Androgen Receptor Signaling Pathway; Apoptosis; Aurora A signaling; Autodegra

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More