p53 is a transcription factor that regulates the cell cycle and hence functions as a tumor suppressor. p53 has been described as "the guardian of the genome", referring to its role in conserving stability by preventing genome mutation. p53 has many anti-cancer mechanisms: activating DNA repair proteins when DNA has sustained damage, holding the cell cycle at the G1/S regulation point on DNA damage recognition, initiating apoptosis if the DNA damage proves to be irrepairable. Human p53 is 393 amino acids long and has three domains: N-terminal transcription-activation domain (TAD), which activates transcription factors. 2) central DNA-binding core domain (DBD). 3) C-terminal homo-oligomerisation domain (OD); tetramerization greatly increases the activity of p53 in vivo. Mutations that deactivate p53 in cancer usually occur in the DBD and most of these mutations destroy the ability of the protein to bind to its target DNA sequences. The activity of p53 is regulated at different levels and includes control by multi-site phosphorylation. p53 is phosphorylated (Ser6 and Ser9) by casein kinase 1δ and casein kinase 1ε both in vitro and in vivo.
Pathway
Activation of BH3-only proteins; Activation of NOXA and translocation to mitochondria; Activation of PUMA and translocation to mitochondria; Amyotrophic lateral sclerosis (ALS); Androgen Receptor Signaling Pathway; Apoptosis; Aurora A signaling; Autodegradation of the E3 ubiquitin ligase COP1; BARD1 signaling events; Basal cell carcinoma; Bladder cancer; Cell Cycle Checkpoints; Cell cycle; Chronic myeloid leukemia; Colorectal cancer
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
Have you cited DPAB2697RH in a publication? Let us know and earn a reward for your research.
Basso, K; Dalla-Favera, R; et al. Roles of BCL6 in normal and transformed germinal center B cells. IMMUNOLOGICAL REVIEWS 247:172-183(2012).
Hagel, C; Krog, B; et al. Prognostic relevance of TP53 mutations, p53 protein, Ki-67 index and conventional histological grading in oligodendrogliomas. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 18:305-309(1999).
Payment methods we support:
Invoice / Purchase Order
Credit card
My Review for Anti-TP53 polyclonal antibody
Creative Diagnostics products are for RESEARCH USE ONLY, please make sure your review is research based.
Required fields are marked with *
Terms and conditions:
We will select high-quality review customers and offer a $30 coupon for your next purchase.
All product reviews must be submitted in the English language.
Creative Diagnostics will not share any personal information of applicants, and all information will be treated with strict confidentiality and will not be sold or disclosed to a third party.
COA
Certificate of Analysis
 Antibody_1.gif)
