Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Pathway
Cytosolic sensors of pathogen-associated DNA; DAI mediated induction of type I IFNs; Hepatitis C; Herpes simplex infection; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;
Citations
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