Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain,
Belongs to the Toll-like receptor family.Contains 22 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 LRRNT domain.Contains 1 TIR domain.
Endoplasmic reticulum membrane. Endosome membrane.
ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18.
Preservative: 0.02% Sodium azideConstituent: PBS
0.02% Sodium Azide
Shipped at 4°C. Store at -20℃. Preservative: 0.02% Sodium azideConstituent: PBS
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]
double-stranded RNA binding; double-stranded RNA binding; protein binding; receptor activity; transmembrane signaling receptor activity;
TLR3; toll-like receptor 3; CD283; IIAE2;