Recombinant fragment corresponding to Human SPARC aa 20-237. (BC004974).Sequence: QQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAE NPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTF DSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRD WLKNVLVTLYERDEDNNLLT
Conjugate
Unconjugated
Applications
Application Notes
IHC-P: 1/100 - 1/500.
Target
Alternative Names
SPARC; secreted protein, acidic, cysteine-rich (osteonectin); ON; cysteine rich protein; osteonectin; BM-40; cysteine-rich protein; basement-membrane protein 40; secreted protein acidic and rich in cysteine;
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Pathway
Hemostasis; Platelet activation, signaling and aggregation; Platelet degranulation; Response to elevated platelet cytosolic Ca2+; Senescence and Autophagy; TGF-beta Receptor Signaling Pathway;
Citations
Publication ()
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