Anti-Osteonectin monoclonal antibody (DMAb6343MH)

Mouse anti-Bovine Osteonectin monoclonal antibody for RIA, WB, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
BPO-5032
Species Reactivity
Bovine
Immunogen
Unfractionatedbovine bone extract
Conjugate
Unconjugated

Target


Alternative Names
ON
Entrez Gene ID
UniProt ID

Product Background


Gene summary
SPARC (Secreted Protein Acidic And Cysteine Rich) is a Protein Coding gene. Diseases associated with SPARC include osteogenesis imperfecta, type xvii and osteogenesis imperfecta, type iv. Among its related pathways are Platelet activation, signaling and aggregation and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and extracellular matrix binding. An important paralog of this gene is SPARCL1. This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene.
Antigen Description
Osteogenesis imperfecta 17 (OI17) [MIM:616507]: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. Note=The disease is caused by mutations affecting the gene represented in this entry. Osteonectin (ON) also known as secreted protein acidic and rich in cysteine (SPARC) or basement-membrane protein 40 (BM-40) is a protein that in humans is encoded by the SPARC gene. Osteonectin is an acidic extracellular matrix glycoprotein that plays a vital role in bone mineralization, cell-matrix interactions, and collagen binding. Osteonectin also increases the production and activity of matrix metalloproteinases, a function important to invading cancer cells within bone. Additional functions of osteonectin beneficial to tumor cells include angiogenesis, proliferation and migration. Overexpression of osteonectin is reported in many human cancers such as breast, prostate and colon.
Pathway
Hemostasis; Platelet activation; Platelet degranulation; Response to elevated plateletcytosolic Ca2+; Senescence and Autophagy; TGF-beta Receptor Signaling Pathway.

Citations


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References


Hudson, AE; Feng, WC; et al. Spreading of embryologically distinct urothelial cells is inhibited by SPARC. JOURNAL OF CELLULAR PHYSIOLOGY 202:453-463(2005).
Honda, MJ; Ohara, T; et al. Preliminary study of tissue-engineered odontogenesis in the canine jaw. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 64:283-289(2006).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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