Anti-SPARC monoclonal antibody, clone NN0668-9O49

Antibody Isotype

IgG1

Clone

NN0668-9O49

Species Reactivity

Human

Immunogen

Recombinant full length Human SPARC protein.

Conjugate

Application Notes

WB: 1/500 - 1/1000; IHC-P: 1/20 - 1/200.

Alternative Names

SPARC; secreted protein, acidic, cysteine-rich (osteonectin); ON; cysteine rich protein; osteonectin; AA517111; Basement membrane protein 40; Basement-membrane protein 40; BM 40; BM-40; BM40; Cysteine rich protein; hm:zeh0062; MGC128090; ON; Osteonectin;

Entrez Gene ID

UniProt ID

Antigen Description

This intronless gene is specifically expressed in the testis, and encodes a protein that is highly homologous to the two subunits of phosphoribosylpyrophosphate synthetase encoded by human X-linked genes, PRPS1 and PRPS2. These enzymes convert pyrimidine, purine or pyridine bases to the corresponding ribonucleoside monophosphates. In vitro transcription/translation and site-directed mutagenesis studies indicate that translation of this mRNA initiates exclusively at a non-AUG (ACG) codon.

Pathway

Hemostasis, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem; Platelet degranulation, organism-specific biosystem; Response to elevated platelet cytosolic Ca2+, organism-specific biosystem; Senescence and Autophagy, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem;