Anti-PTGDS polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment corresponding to Human Prostaglandin D Synthase (Lipocalin).Database link: P41222

Conjugate

Application Notes

WB: 1/200 - 1/1000; ELISA: 1/1000 - 1/5000; IHC-P: 1/15 - 1/100;

Alternative Names

PTGDS; prostaglandin D2 synthase 21kDa (brain); PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS; prostaglandin-H2 D-isomerase; cerebrin-28; PGD2 synthase; beta-trace protein; prostaglandin D synthase; prostaglandin-D2 synthase; glutathione-independent PGD synthase;

Entrez Gene ID

UniProt ID

Antigen Description

Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.

Pathway

Arachidonic acid metabolism; Arachidonic acid metabolism; Eicosanoid Synthesis; Metabolism of lipids and lipoproteins