Anti-PTGDS monoclonal antibody, clone FQ23468

Antibody Isotype

IgG

Clone

FQ23468

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Prostaglandin D Synthase (Lipocalin) aa 100 to the C-terminus. The exact sequence is proprietary.Database link: P41222

Conjugate

Application Notes

WB: 1/1000; IHC-P: 1/100; ICC/IF: 1/100;

Alternative Names

PTGDS; prostaglandin D2 synthase 21kDa (brain); prostaglandin D2 synthase (21kD, brain); prostaglandin-H2 D-isomerase; L PGDS; lipocalin type prostaglandin D synthase; PGDS; cerebrin-28; PGD2 synthase; beta-trace protein; prostaglandin D synthase; prostag

Entrez Gene ID

UniProt ID

Antigen Description

Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.

Pathway

Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Eicosanoid Synthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Prostaglandin Synthesis and Regulation, organism-specific biosystem; prostanoid biosynthesis, organism-specific biosystem.