Specifications
Immunogen
Synthetic peptide: C-YSRTQTLKDELKEK, corresponding to internal sequence amino acids 149-162 of Mouse Prostaglandin D Synthase (Lipocalin) (NP_032989.2).
Applications
Application Notes
WB: 0.1 - 0.3 μg/ml.
Target
Alternative Names
PTGDS; prostaglandin D2 synthase (brain); PGD2; PGDS; 21kDa; PGDS2; Ptgs3; L-PGDS; prostaglandin-H2 D-isomerase; PGD2 synthase; prostaglandin-D2 synthase; glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostag
Product Background
Antigen Description
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
Pathway
Arachidonic acid metabolism; Arachidonic acid metabolism; Arachidonic acid metabolism via COX (Cyclooxygenase) pathway; Folic Acid Network
Citations
Publication ()
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COA
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