Anti-PAK2 monoclonal antibody, clone 4C6

Clone

4C6

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human PAK2.

Conjugate

Application Notes

ELISA (1:10000); WB (1:500-1:2000); Immunohistochemistry (1:200-1:1000); Immunofluorescence (1:200-1:1000) & The optimal working dilution should be determined by the end user.

Alternative Names

PAK2; p21 protein (Cdc42/Rac)-activated kinase 2; p21 (CDKN1A) activated kinase 2; serine/threonine-protein kinase PAK 2; PAK65; PAKgamma; S6/H4 kinase; p58; PAK-2; gamma-PAK; p21-activated kinase 2; p21 (CDKN1A)-activated kinase 2;

Entrez Gene ID

UniProt ID

Antigen Description

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.

Pathway

Activation of Rac, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem;