Tag/Conjugate
Unconjugated
Antigen Description
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]
Function
ATP binding; identical protein binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activator activity
Synonyms
PAK2; p21 protein (Cdc42/Rac)-activated kinase 2; PAK65; PAKgamma; serine/threonine-protein kinase PAK 2; p58; PAK-2; gamma-PAK; S6/H4 kinase; p21-activated kinase 2; p21 (CDKN1A)-activated kinase 2
Citations
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Yu, JS; Chen, WJ; et al. Identification of the regulatory autophosphorylation site of autophosphorylation-dependent protein kinase (auto-kinase) - Evidence that auto-kinase belongs to a member of the p21-activated kinase family. BIOCHEMICAL JOURNAL 334:121-131(1998).
Uhlemann, AC; Muller, C; et al. Inhibition of CD95/Fas-induced DNA degradation by osmotic cell shrinkage. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 10:219-228(2000).
COA
Certificate of Analysis
