NKG2A, NKG2C and NKG2E, are isoforms of the NKG2 lectin-like family. In mice, NKG2 subunits associate with CD94 to form heterodimers at the surface of natural killer (NK) cells.The CD94/NKG2 heterodimer is the receptor for a non-classical MHC class I ligand, which is Qa 1 in the mouse. NKG2 is expressed on NK cells, lymphokine-activated killer (LAK) T cells, and some CD8+ memory T cells.
Park, KS; Park, JH; et al. Inhibitory NKG2A and activating NKG2D and NKG2C natural killer cell receptor genes: susceptibility for rheumatoid arthritis. TISSUE ANTIGENS 72:342-346(2008).
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