Rabbit Anti-Human KLRC1 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthesized peptide derived from internal of human KLRC1.

Conjugate

Application Notes

WB: 1:500-1:3000

General Notes

This product (Catalog No. DPABH-07912) is a rabbit-derived IgG polyclonal antibody raised against human KLRC1. It has been affinity purified by protein A. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
DPABH-07912 is suitable for use in Western blot (WB) (1:500–1:3,000) application.
DPABH-07912 is supplied as a liquid formulation in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

NKG2-A/NKG2-B type II integral membrane protein; NKG2-A/B-activating NK receptor; NK cell receptor A; CD159 antigen-like family member A; CD159a

Entrez Gene ID

UniProt ID