Anti-Morphine monoclonal antibody, clone CDI298

Opioid availability and accessibility represent major challenges to cancer patients, particularly in low- and middle-income countries. When palliative care service is available, referrals mostly occur late during the course of disease. In this retrospective study, we examined the pattern and predictors of opioids utilization during the final hospitalization for patients admitted to a tertiary cancer center in Jordan, we assessed factors contributing to opioid use among patients with cancer during the final hospitalization and estimated opioid use in oral morphine equivalents (OME). A total of 297 patient files were reviewed. Patients received the highest doses of opioids at 48 and 24 h prior to death (median dose 34.8 mg OME and 34.5 mg OME, respectively). The palliative care service prescribed higher OME doses than other services (OR 3.54;P< 0.001). The median OME dose used by patients above 65 years was lower than the dose used by the younger group (OR 1.04/years of age;P< 0.001). Spine and bone metastasis were associated with increased opioid consumption (OR 2.45;P< 0.002). We concluded that palliative care patients received higher doses of opioids in the final hospitalization compared to patients in other services. A palliative care referral may be helpful for patients with pain requiring opioids.

Sulfur-doped carbon nanofibers (SCNFs) were prepared using chemical vapor deposition. In this line, different catalysts and various growth temperatures have been examined to obtain the optimized conditions. Among the employed catalysts, NiFe2O4 showed the most performance, and the best quality of the prepared SCNFs was 600 degrees C. To enhance the electrochemical behaviors, the prepared SCNFs was decorated with gold nanoparticles using electrochemical deposition. Both products (doped and undoped) were fully characterized using common methods. Then, they used for the electrochemical detection of morphine using cyclic voltammetry and square wave voltammetry. The obtained electrochemical diagrams demonstrated the high efficiency of the synthesized product for sensing of morphine.