Morphine (Opiate) Rapid Test

Introduction: Although narcotics are effective for pain relief in these patients, they have little impact on the underlying cause. Therefore, surveys have been conducted to find more effective agents. Objective: This study conducted to compare the analgesic effect of aminophylline and hyoscine combination with morphine on renal colic patients. Methods: This double-blind clinical trial was conducted on patients with renal colic caused by urinary tract stones. Subjects were selected via convenience sampling method. Patients were randomly divided into two groups based on whether they received aminophylline + hyoscine or morphine. Before drug administration, one researcher was asked to measure the pain of the patients using Graduated Numbered Visual Analogue Scale (GN-VAS). Afterward, 20 mg of hyoscine along with 3 mg/kg of aminophylline in 100 cc normal saline was injected during 10 minutes into patients in the one group, whereas 0.1 mg/kg of morphine was intravenously with 100 cc normal saline to align two groups, administered to the subjects in another group. Half an hour after the administration of drugs, pain was measured for the second time. Vital signs and side effects were all recorded. Results: In this study, 95 patients (47 patients in the aminophylline+hyoscine group and 48 patients in the morphine group) remained in the trial until the end. The difference in sex distribution(p=0.227) and age(p=0.680) of the two groups was not statistically significant. Median of pain intensity was not significantly different between the two study groups (p<0.05), neither before nor after administration of the drugs. The mean time required for pain relief in morphine group was significantly lower than aminophylline+hyoscine group (5.9 +/- 1.6 vs. 11.1 +/- 1.6 minutes; p<0.001). Conclusion: Overall, our findings indicated that aminophylline + hyoscine combination was effective in reducing renal colic pain and there is no significant difference between this combination and morphine in terms of pain relief.

Background: Periacetabular osteotomy (PAO) is the standard of care for treatment of symptomatic acetabular dysplasia. Patients undergoing PAO for acetabular dysplasia have postoperative pain that can be managed with epidural analgesia. The purpose of this study was to evaluate the impact of the timing of the discontinuation of epidural analgesia on pain, opioid usage, and hospital length of stay (LOS). The study hypothesis was that removal of the epidural catheter on postoperative day 1 (POD1) would lead to reduced overall opioid usage and LOS compared with removal on POD2. Methods: This is a retrospective before-and-after observational review of the impact of discontinuing epidural analgesia on POD1 versus POD2 in terms of in-hospital pain, opioid usage, and LOS. Baseline patient factors such as age, sex, and body mass index (BMI) as well as outcomes including mean and median of daily pain, total oral morphine milligram equivalents (MMEs) used per day, and LOS were recorded. Descriptive and comparative statistical analyses including multivariable main-effects linear regression modeling were performed to evaluate the impact of the timing of epidural removal on outcomes. Results: Directly comparing outcomes for the day of epidural removal, patients with removal on POD1 had significantly less pain (mean of 4.6 versus 5.1 on the numeric rating scale [NRS], p = 0.033) and opioid usage (130.7 versus 200.4 MMEs, p < 0.001) than patients with removal on POD2. Additionally, LOS (3.3 versus 4.6 days, p < 0.001) and total opioid usage (333.0 versus 674.8 MMEs, p < 0.001) were significantly reduced in patients with epidural removal on POD1. These results persisted in multivariable analyses that were adjusted for age, sex, and BMI. Conclusions: This study demonstrated that patients with epidural removal on POD1 have significantly lower pain and an overall decrease in opioid usage on the date of epidural removal compared with patients undergoing epidural removal on POD2. Additionally, they have a shorter LOS as well as lower total opioid usage. Decreasing the duration of epidural usage may reduce pain, opioid usage, and LOS in patients undergoing PAO.