Anti-MADCAM1 monoclonal antibody, clone FQS7057

Antibody Isotype

IgG

Clone

FQS7057

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to residues in the extracellular domain of Human MAdCAM1.

Conjugate

Application Notes

WB: 1/1000 - 1/10000.

Alternative Names

MADCAM1; mucosal vascular addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule 1; MACAM1; MAdCAM-1; hMAdCAM-1; mucosal addressin cell adhesion molecule-1;

Entrez Gene ID

UniProt ID

Antigen Description

Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.

Pathway

Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem; Integrin cell surface interactions, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem;