Specifications
Immunogen
Synthetic peptide corresponding to residues at the N-terminus of Human MyD88. (Q99836)
Applications
Application Notes
WB: 1/1000 - 1/10000; IHC-P: 1/50 - 1/100; Flow Cyt: 1/500 - 1/10000;
Target
Alternative Names
MYD88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein MyD88; MYD88D;
Product Background
Antigen Description
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway.
Pathway
Activated TLR4 signalling, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem;
Citations
Publication ()
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COA
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