Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway.
Pathway
AGE/RAGE pathway; Activated TLR4 signalling; African trypanosomiasis; Apoptosis; Apoptosis Modulation and Signaling; Chagas disease (American trypanosomiasis); Cytokine Signaling in Immune system; Cytosolic sensors of pathogen-associated DNA;
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