Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
Pathway
Adaptive Immune System; Cell adhesion molecules (CAMs); Cell surface interactions at the vascular wall; Epstein-Barr virus infection; Extracellular matrix organization; HTLV-I infection; Hemostasis; Immune System; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Integrin-mediated cell adhesion; Leukocyte transendothelial migration; Malaria; Natural killer cell mediated cytotoxicity; Rap1 signaling pathway; Regulation of actin cytoskele
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