Anti-INHA monoclonal antibody, clone 4C8

Antibody Isotype

IgG2a

Clone

4C8

Species Reactivity

Human

Immunogen

INHA (AAH06391.1, 1 a.a. ~ 366 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

INHA; inhibin, alpha; inhibin alpha chain; A-inhibin subunit;

Entrez Gene ID

UniProt ID

Antigen Description

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.

Pathway

Glycoprotein hormones, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Ovarian Infertility Genes, organism-specific biosystem; Peptide hormone biosynthesis, organism-specific biosystem;