Anti-INHA monoclonal antibody, clone 5F3

Antibody Isotype

IgG1

Clone

5F3

Species Reactivity

Human; Mouse

Immunogen

Recombinant protein corresponding to human INHA.

Conjugate

Application Notes

ELISA (1:10000); WB (1:500-1:2000); Immunofluorescence (1:200-1:1000) & The optimal working dilution should be determined by the end user.

Alternative Names

INHA; inhibin, alpha; inhibin alpha chain; A-inhibin subunit;

Entrez Gene ID

UniProt ID

Antigen Description

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.

Pathway

Glycoprotein hormones, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Ovarian Infertility Genes, organism-specific biosystem; Peptide hormone biosynthesis, organism-specific biosystem;