Mouse anti-Human Granzyme B (GZMB) Monoclonal antibody, clone HAC02

Antibody Isotype

IgG2a

Clone

HAC02

Species Reactivity

Human

Immunogen

BALB/C mice were injected with recombinant protein encoding the N-terminus of the mature granzyme B.

Conjugate

Alternative Names

GZMB; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1; granzyme B; C11; CTLA-1; fragmentin 2; fragmentin-2; cathepsin G-like 1; human lymphocyte protein; T-cell serine protease 1-3E; cytotoxic serine protease B; cytotoxic T-lymphocyte proteinase

Entrez Gene ID

UniProt ID

Antigen Description

Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells which bear on their surface "nonself" antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Pathway

Activation, myristolyation of BID and translocation to mitochondria; Allograft rejection; Apoptosis; Autoimmune thyroid disease; Caspase cascade in apoptosis; Downstream signaling in naive CD8+ T cells; Graft-versus-host disease; IL12-mediated signaling e