Anti-Human Granzyme B (GZMB) Antibody (DMAB5477MH)

Mouse anti-Human Granzyme B (GZMB) Monoclonal antibody [clone HAC02] for IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
HAC02
Immunogen
BALB/C mice were injected with recombinant protein encoding the N-terminus of the mature granzyme B.
Conjugate
Unconjugated

Target


Alternative Names
GZMB; HLP; CCPI; CGL1; CSPB; SECT
Entrez Gene ID
UniProt ID

Product Background


Pathway
Activation, myristolyation of BID and translocation to mitochondria; Allograft rejection; Apoptosis; Autoimmune thyroid disease; Caspase cascade in apoptosis; Downstream signaling in naive CD8+ T cells; Graft-versus-host disease; IL12-mediated signaling e

Citations


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References


Urbanellis, P; Shyu, W; et al. The regulatory T cell effector molecule fibrinogen-like protein 2 is necessary for the development of rapamycin-induced tolerance to fully MHC-mismatched murine cardiac allografts. IMMUNOLOGY 144:91-106(2015).
Bade, B; Boettcher, HE; et al. Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes. INTERNATIONAL IMMUNOLOGY 17:1419-1428(2005).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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