Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Granzyme B. Lys17-Ser247 Accession Number P04187
Applications
Application Notes
Western Blot 0.1 μg/mL; Immunocytochemistry 5-15 μg/mL Immunohistochemistry 5-15 μg/mL; ELISA Capture 0.2-0.8 μg/mL; ELISA Detection 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DPABY-278 - DPABY-543
Target
Alternative Names
GZMB; granzyme B; GZB; CCP1; Ctla1; Ctla-1; AI553453; CCP-1/C11; granzyme B(G,H); fragmentin-2; cytotoxic cell protease 1;
Product Background
Antigen Description
Granzyme family serine proteases are stored in the granules of cytotoxic T lymphocytes and natural killer cells. Granzymes contain one S1 protease domain and are synthesized as preproproteins. Granzymes are released toward pathogen infected or transformed target cells during cellular immune reactions. Target cell entry by granzymes is through perforin channels. Granzymes trigger apoptosis by caspase-dependent and -independent mechanisms. There are five granzymes (A, B, G, H and K) in human and many more in mouse and rat.
Pathway
Activation, myristolyation of BID and translocation to mitochondria; Allograft rejection; Apoptosis; Autoimmune thyroid disease; Graft-versus-host disease; Intrinsic Pathway for Apoptosis; NOTCH2 intracellular domain regulates transcription; Natural kille
Citations
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Kurschus, FC; Kleinschmidt, M; et al. Killing of target cells by redirected granzyme B in the absence of perforin. FEBS LETTERS 562:87-92(2004).
Crosby, EJ; Goldschmidt, MH; et al. Engagement of NKG2D on Bystander Memory CD8 T Cells Promotes Increased Immunopathology following Leishmania major Infection. PLOS PATHOGENS 10:-(2014).
COA
Certificate of Analysis
