Specifications
Immunogen
This antibody was generated by genetic immunisation of BALB/c mice with an immunisation vector containing the granzyme B cDNA.
Target
Alternative Names
GZMB; granzyme B; granzyme B(G,H); fragmentin-2; cytotoxic cell protease 1; GZB; CCP1; Ctla1; Ctla-1; AI553453; CCP-1/C11;
Product Background
Antigen Description
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Pathway
Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem;
Citations
Publication ()
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COA
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