GSN (AAH26033, 673 a.a. ~ 782 a.a) partial recombinant protein with GST tag. The sequence is SNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIE TDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSVDPLDRAMAELAA
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
Pathway
Amyloids; Apoptotic cleavage of cellular proteins; Caspase cascade in apoptosis; Coregulation of Androgen receptor activity
Citations
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