Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide corresponding to residues near the C terminal region of Human Gelsolin (UniProt P06396).
Applications
Application Notes
WB: 1/1000 - 1/5000; IHC-P: 1/100 - 1/250;
Target
Alternative Names
GSN; gelsolin; gelsolin (amyloidosis, Finnish type); amyloidosis; Finnish type; DKFZp313L0718; brevin; actin-depolymerizing factor; ADF; AGEL;
Product Background
Antigen Description
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Pathway
Amyloids, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem;
Citations
Publication ()
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COA
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